… In addition, they are inhibit CDK5 enzyme using roscovitine as a … Molecular modelling and
docking study … Å, the previous theoretical results obtained from molecular docking proved the …

… SF-539 cell line were obtained with the best results, using Roscovitine as a positive control.
… , but also inhibits CDK5, that is involved in cell migration. This dual effect make Roscovitine a …

… Roscovitine is one of the first generation CDK inhibitors, ATP … is attributed to CDK1, CDK2
and CDK5 inhibition [11]. It … The molecular modeling study was carried out using Molecular …

… of the CDK5 in complex with inhibitor R-Roscovitine. It is a bi-… the most potent inhibitor of the
CDK5/p25 complex with IC 50 … peptide inhibitor of CDK5 composed of 126 residues derived …

… All of them showed potent inhibition against CDK5/P25 and … of roscovitine stimulated the
discovery of other CDK inhibitors, … as candidates for the molecular modeling study to understand …

… of active CDK5 protein bound with its ligand roscovitine (… Compound 29 was identified as
the most potent inhibitor with … through SiRNA/shRNA caused apoptosis in cells derived from …

… Molecular modeling of 25–106 as compared to another Cdk5 inhibitor, roscovitine, revealed
that 25–… Any product that may be evaluated in this article, or claim that may be made by its …

… potent inhibitor of Cdks and obtained low IC 50 value (1 nM) against Cdk5 with higher inhibition
… interaction pattern of Cdk5 and its state-of-the-art inhibitor (R)-roscovitine and identified …

… Besides, the small molecule roscovitine (seliciclib) inhibited CDKs 2 and 5 with suspending
… of the HI 5, a potential competitive inhibitor of the CDK2. The obtained results have valuable …

… Roscovitine, aloisine, and indirubin, the inhibitors disclosed in this study, … as molecular
probes to learn more about CDK5's function in neurodegenerative diseases therapy. We obtained …